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中文核心期刊

脉冲噪声暴露后豚鼠畸变产物可声发射(DPO)和耳蜗振电压(CM)的变化

Changes in distortion product otoacoustic emissions (DPO) and cochlear microphonics (CM) induced by impulse noise exposure in Guinea Pigs

  • 摘要: 脉冲声暴露前及暴露后即刻(1小时之内)、48小时、一周同时测试了豚鼠耳蜗畸变产物耳声发射(DPO)和振电压(CM),结果表明,暴露前豚鼠耳蜗出现最佳DPO的最适频比(f2/f1)为1.19-1.25,最适强度差(If1-If2)为0.45-2.00dB,8和4kHz时DPO出现率为100%,2kHz为95%,1kHz时为79%。暴露后不同阶段DPO和CM恢复的速率和变化程度不同,前者在各个阶段上损失的程度比后者重。震后一周DPO除在8kHz时恢复至接近震前水平外,其余频率只恢复至震前的1/4左右或稍多.与之对比,各个频率的CM在一周时均完全恢复至震前水平,似说明DPO较CM敏感。DPO和CM相关分析结果提示,二者同源于外毛细胞(OHC).

     

    Abstract: Distortion product otoacoustic emissions (DPO) and cochlear microphonics (CM) were recorded before and 1, 48 hours, and 1 week after impulse noise exposure in guinea pigs. The results showed that before noise exposure, the adequate frequency ratios (f2/f1) and adequate intensity difference (If1-If2) were between 1.19-1.25 and 0.45-2.00 dB, respectively. The incidence of appearance of DPO was 100% at 8 and 4 kHz, 95% at 2 kHz and 79% at 1 kHz. After noise exposure, the changes and recovery rate of DPO differed from those of CM in all periods. In particular, changes in DPO were greater than those of CM. DPO at all frequencies recovered only to about 1/4 of the pre-exposure level, with the only exception that recovery was complete after 1 week at 8 kHz. In contrast, CM at all frequencies recovered to the pre-exposure level at the same time. The results seem to indicate that DPO is more sensitive to noise exposure than CM and, also, that the former changes proir to CM. Correlation analysis between DPO and CM suggests that both originate from the outer hair cells (OHC).

     

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