摘要:
平均骨小梁间距作为松质骨微结构的重要表征参数,其值可作为诊断骨质疏松的重要参考信息。提出将二次变换法运用于骨小梁间距的估算,探究其运用于骨小梁间距估算的可行性。通过散射元仿真、时域有限差分法仿真和离体松质骨实验所得到松质骨背散射信号进行分析,同时以自回归倒谱法(AR倒谱法)、反向滤波-自回归倒谱法(反向滤波-AR倒谱法)、自适应滤波-自回归倒谱法(自适应滤波-AR倒谱法)和简易反向滤波跟踪(SIFT)算法作为对比方法进行分析,通过对比证明了其可行性和相比于其他方法的优越性。结果表明,不管是利用仿真实验还是牛胫骨的离体实验所得信号估算骨小梁间距,二次变换法比其他算法具有更强的测量稳定性和准确性。
Abstract:
As an important characterization parameter of cancellous bone microarchitecture,mean trabecular bone spacing (TbSp) serves as an important index for osteoporosis diagnosis.An estimation method for TbSp,quadratic transformation method QT),was introduced.The superiority of this algorithm was approved by scatter simulation,finite difference time domain (FDTD) numerical simulation and in vitro experiment with cancellous bone specimens of bovine tibia,compared with four existing methods,auto regressive cepstrum (AR),adaptive filter-autoregressive cepstral (AFAR),inverse filter-auto regressive cepstrum (InvAR),simplified inverse filter tracking (SIFT) algorithms.The results of the simulations and experiment indicate that QT is much more stable and accurate than the other four existing methods.
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