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中文核心期刊

动态监测骨质疏松性微结构退化的超声全波反演方法

Ultrasonic full-waveform inversion for dynamically monitoring bone micro-structure deterioration in osteoporosis progression

  • 摘要: 研究了基于全波反演(FWI)的骨骼超声层析成像方法, 用于动态监测骨质疏松性微结构退化的进程。采用雌性小鼠注射药物建立骨质疏松症模型, 在第0, 2, 4, 6周通过Micro-CT扫描活体小鼠, 重建获得小鼠股骨骨骼结构。以第0周骨骼结构为基准输入模型, 通过不同的超声收发模式(透射、反射及透射−反射双模式), 仿真分析了FWI监测不同骨质疏松进程的骨微结构退化的效果。结果表明, 初始模型为均匀介质(纯水)时, FWI反演失效, 不能准确重建骨骼结构。初始模型中考虑了基准骨骼结构(第0周)时, FWI能准确反演骨骼组织声速(均方根误差(RMSE) < 17 m/s, 平均相对误差(MRE) < 7.2%), 精确重建骨骼结构(结构相关系数(CC) > 0.85)), 因此可以准确监测不同骨质疏松进程(第2, 4, 6周)的骨微结构退化情况。对比不同超声收发模式, 透射−反射双模式FWI监测骨微结构退化的性能优于单一透射或反射FWI监测方法。考虑了基准骨骼模型的FWI可用于动态监测骨微结构退化, 对评估骨质疏松进展具有一定意义。

     

    Abstract: The aim of this study is to investigate the method of ultrasound tomography of bone based on ultrasonic full-waveform inversion (FWI), and to dynamically monitor the progression of osteoporotic micro-structural deterioration. Female mice are injected with 4-vinylcyclohexene diepoxide (VCD) to induce premature ovarian failure and establish the mice osteoporosis model. The mice are scanned by Micro-CT in vivo at different osteoporosis progression (the 0, 2, 4 and 6 weeks), and bone micro-structure in the femurs of mice are reconstructed. Taking the initial bone micro-structure of mice (at the 0 week) as the baseline input model, the effects of FWI on monitoring bone micro-structure deterioration in osteoporosis progression are numerically analyzed, with different ultrasound transmitting and receiving modes (transmission, reflection and transmission-reflection dual mode). The results show that FWI failed to reconstruct bone micro-structure when using the uniform medium (pure water) as the initial model. Compared with the initial model with uniform medium (pure water), the FWI using the baseline bone (at the 0 week) model could accurately monitor the bone micro-structure deterioration in different osteoporotic processes (at the 2, 4, 6 week), the ultrasound velocity inversion is with a root-mean-square error (RMSE) < 17 m/s, mean relative error (MRE) < 7.2%, and structural correlation coefficient (CC) > 0.85. Compared with different ultrasound transmitting and receiving modes, the combination of transmission-reflection dual-mode in FWI is significantly superior to the single transmission or reflection FWI in monitoring bone micro-structural deterioration. This study demonstrate that FWI using the baseline bone model can be used to dynamically monitor bone micro-structural deterioration and might have some significance in assessing the progression of osteoporosis.

     

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