哮喘音模型研究

A study on wheezes models

摘要: 本文应用有限差分方法研究了哮喘音的线性与非线性模型,对哮喘音进行了波形分析。实验结果表明:线性模型的数值结果与Grotberg等人的理论分析结果吻合。非线性模型的数值结果与我们的实验结果一致。非线性弹性系数在哮喘音产生中起阻尼作用,它可能与气道塌陷及气流流量限制有密切关系。哮喘音是气道壁与气流相互作用而产生的声信号,气道壁颤振是受迫振动,而不是自激振动。

Abstract: In this paper, finite difference schemes for linear and nonlinear models of wheezes are given. The waveform of wheezes is analysed. The authors show that numerical results of the linear model of wheezes coincide well with Grotberg's theoretical results, while numerical results of the nonlinear model of wheezes are in qualitative agreement with our experimental observations. It is suggested that, the nonlinear elastance coefficient (β) causes damping and is closely related with the flow limitation and the airway collapse. Wheezes result from the interaction between the fluid force and the wall force, and the airway wall flutter is a forced-vibration rather than a self-vibration.